~ Jonathan D. Clayden

I am a Research Fellow in brain imaging and tractography methods at the Institute of Child Health at University College London, where I'm working with Chris Clark. In 2007 I completed my PhD in Neuroinformatics at the University of Edinburgh. (My thesis is available on this site.)

My research interests include the development of methods to help improve scientific understanding of connectivity and function in the healthy and unhealthy human brain. One important tool that is available to explore connectivity is diffusion magnetic resonance imaging based fibre tracking, which can elucidate the patterns of “wiring” in the living brain. It is assumed that if these pathways are interrupted, the brain will become internally disconnected, with negative consequences for cognition.

Software

I am the author and maintainer of the TractoR diffusion MRI analysis project, which consists of a set of tools for performing tractography and white matter segmentation using methods described in some of the publications listed below. TractoR is free software, available under the GPL licence (version 2).

Publications

My PhD thesis has a page of its own.

Journal papers

J.D. Clayden, A.J. Storkey, S. Muñoz Maniega & M.E. Bastin (in press). Reproducibility of tract segmentation between sessions using an unsupervised modelling-based approach. To appear in NeuroImage. [pdf (1724 KiB)]

E. Sprooten, G.K.S. Lymer, S. Muñoz Maniega, J. McKirdy, J.D. Clayden, M.E. Bastin, D.J. Porteous, E.C. Johnstone, S.M. Lawrie, J. Hall & A.M. McIntosh (in press). The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants. To appear in Molecular Psychiatry.

M.E. Bastin, J.D. Clayden, A. Pattie, I.F. Gerrish, J.M. Wardlaw & I.J. Deary (2009). Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age. Neurobiology of Aging 30(1):125-136. [PubMed; ScienceDirect]

A.M. McIntosh, S. Muñoz Maniega, G.K.S. Lymer, J. McKirdy, J. Hall, J.E.D. Sussmann, M.E. Bastin, J.D. Clayden, E.C. Johnstone & S.M. Lawrie (2008). White matter tractography in bipolar disorder and schizophrenia. Biological Psychiatry 64(12):1088-1092. [PubMed; ScienceDirect]

M.E. Bastin, J.P. Piątkowski, A.J. Storkey, L.J. Brown, A.M. MacLullich & J.D. Clayden (2008). Tract shape modelling provides evidence of topological change in corpus callosum genu during normal ageing. NeuroImage 43(1):20-28. [ScienceDirect]

J.D. Clayden, A.J. Storkey & M.E. Bastin (2007). A probabilistic model-based approach to consistent white matter tract segmentation. IEEE Transactions on Medical Imaging 26(11):1555-1561. [pdf (1040 KiB); IEEE Xplore]

J.D. Clayden, M.E. Bastin & A.J. Storkey (2006). Improved segmentation reproducibility in group tractography using a quantitative tract similarity measure. NeuroImage 33(2):482-492. [pdf (1061 KiB); PubMed; ScienceDirect]

I.J. Deary, M.E. Bastin, A. Pattie, J.D. Clayden, L.J. Whalley, J.M. Starr & J.M. Wardlaw (2006). White matter integrity and cognition in childhood and old age. Neurology 66(4):505-512. [PubMed]

Peer-reviewed conference abstracts

J.D. Clayden, A.J. Storkey & M.E. Bastin (2008). A comparison of seeding strategies for group tractography. In Proceedings of the ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada; p. 1839. [pdf (237 KiB)]

J.D. Clayden, A.J. Storkey & M.E. Bastin (2008). Probabilistic combination of tractography data from multiple seed points for white matter segmentation. In Proceedings of the ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada; p. 1840. [pdf (164 KiB)]

S. Muñoz Maniega, M.E. Bastin, A.M. McIntosh, S.M. Lawrie & J.D. Clayden (2008). Atlas-based reference tracts improve automatic white matter segmentation with neighbourhood tractography. In Proceedings of the ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada; p. 3318. [pdf (261 KiB)]

M.E. Bastin, J.D. Clayden, J.P. Piątkowski, A.J. Storkey, L.J. Brown & A.M. MacLullich (2008). Robust segmentation of white matter tracts in the aging brain. In Proceedings of the ISMRM 16th Scientific Meeting & Exhibition, Toronto, Canada; p. 2092. [pdf (76 KiB)]

J.D. Clayden, A.J. Storkey & M.E. Bastin (2007). A probabilistic model-based approach to consistent white matter tract segmentation. In Proceedings of the ISMRM-ESMRMB Joint Annual Meeting, Berlin, Germany; p. 78. [pdf (127 KiB)]

J.D. Clayden, S. Zhang, S. Correia & D.H. Laidlaw (2007). Fine-grained comparison of anisotropy differences between groups of white matter tracts. In Proceedings of the ISMRM-ESMRMB Joint Annual Meeting, Berlin, Germany; p. 82. [pdf (138 KiB)]

M.E. Bastin, J.D. Clayden, A. Pattie, I.F. Gerrish, J.M. Wardlaw & I.J. Deary (2007). DTI and MTI parameters correlate in periventricular white matter hyperintensities in old age. In Proceedings of the ISMRM-ESMRMB Joint Annual Meeting, Berlin, Germany; p. 2160. [pdf (44 KiB)]

J.D. Clayden, M.E. Bastin & A.J. Storkey (2006). Neighbourhood tractography: a new approach to seed point placement for group fibre tracking. In Proceedings of the British Chapter of the ISMRM, Guildford, UK; p. P34. [pdf (422 KiB)]

J.D. Clayden, M.E. Bastin & A.J. Storkey (2006). Automated assessment of tract similarity in group diffusion MRI data. In Proceedings of the ISMRM 14th Scientific Meeting & Exhibition, Seattle, USA; p. 2742. [pdf (118 KiB)]

J.D. Clayden, D.K.S. Marjoram, M.E. Bastin, E.C. Johnstone & S.M. Lawrie (2005). Towards an automated method for white matter integrity comparison between populations. In Proceedings of the ESMRMB 22nd Annual Meeting, Basel, Switzerland; p. 508.

I.J. Deary, M.E. Bastin, A. Pattie, J.D. Clayden & J.M. Wardlaw (2005). Cognitive ageing and white matter integrity: a diffusion tensor and magnetisation transfer MRI study. In Proceedings of the ISMRM 13th Scientific Meeting & Exhibition, Miami, USA. [pdf (25 KiB)]

I.J. Deary, M.E. Bastin, A. Pattie, J.D. Clayden, J.M. Starr & J.M. Wardlaw (2005). White matter integrity and cognition in childhood and old age: a diffusion tensor MRI study. Methods for Quantitative MRI of Human Brain. ISMRM Workshop, Lake Louise, Canada. [pdf (40 KiB)]

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Everything not work related can be found on my other site. A slowly accumulating group of computing (LaTeX, UNIX, etc.) related tips may be of interest to some.

Copyright (c) 2008 Jon Clayden. Any views or opinions expressed on this site are my own and not those of UCL.